Article
The Saccharomyces cerevisiae F-box protein Dia2 is a mediator of S-phase checkpoint recovery from DNA damage.
Genetics - 1 Feb 2013
Fong Chi Meng, Arumugam Ashwini, Koepp Deanna M
Abstract excerpt
Cell-cycle progression is monitored by checkpoint pathways that pause the cell cycle when stress arises to threaten the integrity of the genome. Although activation of checkpoint pathways has been extensively studied, our understanding of how cells resume the cell cycle when the stress is resolved is relatively limited. In this study, we identify the Saccharomyces cerevisiae F-box protein Dia2 as a novel player...
Topics
- Alleles
- Cell Cycle Proteins
- Checkpoint Kinase 2
- DNA Damage
- DNA Replication
- F-Box Proteins
- Methyl Methanesulfonate
- Mutagens
- Mutation
- Protein Serine-Threonine Kinases
- Proteolysis