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Article

The SCFDia2 ubiquitin E3 ligase ubiquitylates Sir4 and functions in transcriptional silencing.

PLoS genetics - 1 Jan 2012

Burgess Rebecca J, Zhou Hui, Han Junhong, Li Qing, Zhang Zhiguo

Abstract excerpt

In budding yeast, transcriptional silencing, which is important to regulate gene expression and maintain genome integrity, requires silent information regulator (Sir) proteins. In addition, Rtt106, a histone chaperone involved in nucleosome assembly, functions in transcriptional silencing. Howeve...

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Identifiers

PMID: 22844255
DOI: 10.1371/journal.pgen.1002846
PMCID: PMC3405993

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026. Prepared record publication-22844255-2026-09-04.2. Manifest publication-graph-cohort-2026-09-04.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 4 Sept 2026.

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The SCFDia2 ubiquitin E3 ligase ubiquitylates Sir4 and functions in transcriptional silencing.PMID 22844255Read ↗

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