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Article

Disease-associated DNA2 nuclease-helicase protects cells from lethal chromosome under-replication.

Nucleic acids research - 27 Jul 2020

Falquet Benoît, Ölmezer Gizem, Enkner Franz, Klein Dominique, Challa Kiran, Appanah Rowin, Gasser Susan M, Rass Ulrich

Abstract excerpt

DNA2 is an essential nuclease-helicase implicated in DNA repair, lagging-strand DNA synthesis, and the recovery of stalled DNA replication forks (RFs). In Saccharomyces cerevisiae, dna2Δ inviability is reversed by deletion of the conserved helicase PIF1 and/or DNA damage checkpoint-mediator RAD9. It has been suggested that Pif1 drives the formation of long 5'-flaps during Okazaki fragment maturation, and that the...

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Identifiers

PMID: 32544229
DOI: 10.1093/nar/gkaa524
PMCID: PMC7367196

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Source receipt: pubmed, retrieved 7 Sept 2026.

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