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Article

'Edgetic' perturbation of a C. elegans BCL2 ortholog.

Nature methods - 1 Nov 2009

Dreze Matija, Charloteaux Benoit, Milstein Stuart, Vidalain Pierre-Olivier, Yildirim Muhammed A, Zhong Quan, Svrzikapa Nenad, Romero Viviana, Laloux Géraldine, Brasseur Robert, Vandenhaute Jean, Boxem Mike, Cusick Michael E, Hill David E, Vidal Marc

Abstract excerpt

Genes and gene products do not function in isolation but within highly interconnected 'interactome' networks, modeled as graphs of nodes and edges representing macromolecules and interactions between them, respectively. We propose to investigate genotype-phenotype associations by methodical use of alleles that lack single interactions, while retaining all others, in contrast to genetic approaches designed to...

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Source

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Identifiers

PMID: 19855391
DOI: 10.1038/nmeth.1394
PMCID: PMC2865203

Genes

BCL2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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