Article
Edgetic perturbation models of human inherited disorders.
Molecular systems biology - 1 Jan 2009
Zhong Quan, Simonis Nicolas, Li Qian-Ru, Charloteaux Benoit, Heuze Fabien, Klitgord Niels, Tam Stanley, Yu Haiyuan, Venkatesan Kavitha, Mou Danny, Swearingen Venus, Yildirim Muhammed A, Yan Han, Dricot Amélie, Szeto David, Lin Chenwei, Hao Tong, Fan Changyu, Milstein Stuart, Dupuy Denis, Brasseur Robert, Hill David E, Cusick Michael E, Vidal Marc
Abstract excerpt
Cellular functions are mediated through complex systems of macromolecules and metabolites linked through biochemical and physical interactions, represented in interactome models as 'nodes' and 'edges', respectively. Better understanding of genotype-to-phenotype relationships in human disease will require modeling of how disease-causing mutations affect systems or interactome properties. Here we investigate how...
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