Article
A Strategy To Isolate Modifiers of Caenorhabditis elegans Lethal Mutations: Investigating the Endoderm Specifying Ability of the Intestinal Differentiation GATA Factor ELT-2.
G3 (Bethesda, Md.) - 4 May 2018
Wiesenfahrt Tobias, Duanmu Jingjie, Snider Frances, Moerman Don, Au Vinci, Li-Leger Erica, Flibotte Stephane, Parker Dylan M, Marshall Craig J, Nishimura Erin Osborne, Mains Paul E, McGhee James D
Abstract excerpt
The ELT-2 GATA factor normally functions in differentiation of the C. elegans endoderm, downstream of endoderm specification. We have previously shown that, if ELT-2 is expressed sufficiently early, it is also able to specify the endoderm and to replace all other members of the core GATA-factor transcriptional cascade (END-1, END-3, ELT-7). However, such rescue requires multiple copies (and presumably...
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