Article

CRISPR-based editing reveals edge-specific effects in biological networks

2018-02-15

Abstract excerpt

Unraveling the properties of biological networks is central to understanding normal and disease cellular phenotypes. Networks consist of functional elements (nodes) that form a variety of diverse connections (edges) with each node being a hub for multiple edges. Herein, in contrast to node-centric network perturbation and analysis approaches, we present a high-throughput CRISPR-based methodology for delineating th...

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Literature Corpus work: 118f6fae-2762-5ede-9c2a-4fc6607c2d2d
DOI: 10.1101/265710

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