Article
Combined functional genomic maps of the C. elegans DNA damage response.
Science (New York, N.Y.) - 4 Jan 2002
Boulton Simon J, Gartner Anton, Reboul Jérôme, Vaglio Philippe, Dyson Nick, Hill David E, Vidal Marc
Abstract excerpt
Many human cancers originate from defects in the DNA damage response (DDR). Although much is known about this process, it is likely that additional DDR genes remain to be discovered. To identify such genes, we used a strategy that combines protein-protein interaction mapping and large-scale phenotypic analysis in Caenorhabditis elegans. Together, these approaches identified 12 worm DDR orthologs and 11 novel DDR...
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