Article
The pro-apoptotic function of the C. elegans BCL-2 homolog CED-9 requires interaction with the APAF-1 homolog CED-4.
Science advances - 11 Oct 2024
Tucker Nolan, Reddien Peter, Hersh Bradley, Lee Dongyeop, Liu Mona H X, Horvitz H Robert
Abstract excerpt
In Caenorhabditis elegans, apoptosis is inhibited by the BCL-2 homolog CED-9. Although canonically anti-apoptotic, CED-9 has a poorly understood pro-apoptotic function. CED-9 is thought to inhibit apoptosis by binding to and inhibiting the pro-apoptotic C. elegans APAF-1 homolog CED-4. We show that CED-9 or CED-4 mutations located in their CED-9-CED-4 binding regions reduce apoptosis without affecting the CED-9...
Topics
- Animals
- Caenorhabditis elegans Proteins
- Caenorhabditis elegans
- Apoptosis
- Apoptotic Protease-Activating Factor 1
- Proto-Oncogene Proteins c-bcl-2
- Mitochondria
- Protein Binding
- Mutation
- Calcium-Binding Proteins