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Article

Protein-protein interactions and networks: forward and reverse edgetics.

Methods in molecular biology (Clifton, N.J.) - 1 Jan 2011

Charloteaux Benoit, Zhong Quan, Dreze Matija, Cusick Michael E, Hill David E, Vidal Marc

Abstract excerpt

Phenotypic variations of an organism may arise from alterations of cellular networks, ranging from the complete loss of a gene product to the specific perturbation of a single molecular interaction. In interactome networks that are modeled as nodes (macromolecules) connected by edges (interactions), these alterations can be thought of as node removal and edge-specific or "edgetic" perturbations, respectively....

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PMID: 21863489
DOI: 10.1007/978-1-61779-173-4_12

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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