Systematic interactome mapping and genetic perturbation analysis of a C. elegans TGF-beta signaling network.

doi:10.1016/s1097-2765(04)00033-4

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Community

Back to search

Article

Systematic interactome mapping and genetic perturbation analysis of a C. elegans TGF-beta signaling network.

Molecular cell - 27 Feb 2004

Tewari Muneesh, Hu Patrick J, Ahn Jin Sook, Ayivi-Guedehoussou Nono, Vidalain Pierre-Olivier, Li Siming, Milstein Stuart, Armstrong Chris M, Boxem Mike, Butler Maurice D, Busiguina Svetlana, Rual Jean-François, Ibarrola Nieves, Chaklos Sabrina T, Bertin Nicolas, Vaglio Philippe, Edgley Mark L, King Kevin V, Albert Patrice S, Vandenhaute Jean, Pandey Akhilesh, Riddle Donald L, Ruvkun Gary, Vidal Marc

Abstract excerpt

To initiate a system-level analysis of C. elegans DAF-7/TGF-beta signaling, we combined interactome mapping with single and double genetic perturbations. Yeast two-hybrid (Y2H) screens starting with known DAF-7/TGF-beta pathway components defined a network of 71 interactions among 59 proteins. Coaffinity purification (co-AP) assays in mammalian cells confirmed the overall quality of this network. Systematic...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Caenorhabditis elegans Proteins

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Cosmids

Share to Genes, Helminth

Share to Proteome

Share to RNA, Small Interfering

Share to Transforming Growth Factor beta

Share to Transgenes

Share to Two-Hybrid System Techniques

Source

Open in PubMed

Identifiers

PMID: 14992718
DOI: 10.1016/s1097-2765(04)00033-4

Genes

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Systematic interactome mapping and genetic perturbation analysis of a C. elegans TGF-beta signaling network.PMID 14992718Read ↗

Transcriptomic Profiling of DAF-7/TGFβ Pathway Mutants in C. elegans.Semantic proximity Read ↗

A map of the interactome network of the metazoan C. elegans.Semantic proximity Read ↗

Systematic mapping of genetic interactions in Caenorhabditis elegans identifies common modifiers of diverse signaling pathways.Semantic proximity Read ↗

A combined binary interaction and phenotypic map of C. elegans cell polarity proteins.Semantic proximity Read ↗

A genome-wide RNAi screen identifies potential drug targets in a C. elegans model of α1-antitrypsin deficiency.Semantic proximity Read ↗

DAF-5 is a Ski oncoprotein homolog that functions in a neuronal TGF beta pathway to regulate C. elegans dauer development.Semantic proximity Read ↗

Inferring gene function and network organization in Drosophila signaling by combined analysis of pleiotropy and epistasis.Semantic proximity Read ↗

Information-based methods for predicting gene function from systematic gene knock-downs.Semantic proximity Read ↗

Combined functional genomic and proteomic approaches identify a PP2A complex as a negative regulator of Hippo signaling.Semantic proximity Read ↗

C. elegans serine-threonine kinase KIN-29 modulates TGFbeta signaling and regulates body size formation.Semantic proximity Read ↗

Networks in Caenorhabditis elegans.Semantic proximity Read ↗

Discovery of nonautonomous modulators of activated Ras.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.