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Article

Inactivation of Notch signaling in the renal collecting duct causes nephrogenic diabetes insipidus in mice.

The Journal of clinical investigation - 1 Nov 2009

Jeong Hyun-Woo, Jeon Un Sil, Koo Bon-Kyoung, Kim Wan-Young, Im Sun-Kyoung, Shin Juhee, Cho Yunje, Kim Jin, Kong Young-Yun

Abstract excerpt

The heterogeneous cellular composition of the mammalian renal collecting duct enables regulation of fluid, electrolytes, and acid-base homeostasis, but the molecular mechanism of its development has yet to be elucidated. The Notch signaling pathway is involved in cell fate determination and has been implicated in proximal-distal patterning in the mammalian kidney. To investigate the role of Notch signaling in...

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Share to Cell Differentiation
Share to Diabetes Insipidus, Nephrogenic

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Gene Expression

Share to Kidney Tubules, Collecting

Share to Mice, Inbred C57BL

Share to Mice, Transgenic

Share to Receptors, Notch

Share to Ubiquitin-Protein Ligases

Source

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Identifiers

PMID: 19855135
DOI: 10.1172/JCI38416
PMCID: PMC2769200

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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