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Article

Uroplakin 1b is critical in urinary tract development and urothelial differentiation and homeostasis.

Kidney international - 1 Mar 2016

Carpenter Ashley R, Becknell M Brian, Ching Christina B, Cuaresma Edward J, Chen Xi, Hains David S, McHugh Kirk M

Abstract excerpt

Proper development and maintenance of urothelium is critical to its function. Uroplakins are expressed in developing and mature urothelium where they establish plaques associated with the permeability barrier. Their precise functional role in development and disease is unknown. Here, we disrupted Upk1b in vivo where its loss resulted in urothelial plaque disruption in the bladder and kidney. Upk1b(RFP/RFP)...

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Identifiers

PMID: 26880456
DOI: 10.1016/j.kint.2015.11.017
PMCID: PMC4757817

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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