Article
Adam10 mediates the choice between principal cells and intercalated cells in the kidney.
Journal of the American Society of Nephrology : JASN - 1 Jan 2015
Guo Qiusha, Wang Yinqiu, Tripathi Piyush, Manda Kalyan R, Mukherjee Malini, Chaklader Malay, Austin Paul F, Surendran Kameswaran, Chen Feng
Abstract excerpt
A disintegrin and metalloproteinase domain 10 (Adam10), a member of the ADAM family of cell membrane-anchored proteins, has been linked to the regulation of the Notch, EGF, E-cadherin, and other signaling pathways. However, it is unclear what role Adam10 has in the kidney in vivo. In this study, we showed that Adam10 deficiency in ureteric bud (UB) derivatives leads to a decrease in urinary concentrating ability,...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.