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Article

Abnormal renal phenotype in L1 knockout mice: a novel cause of CAKUT.

Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association - 1 Jan 2002

Debiec Hanna, Kutsche Michael, Schachner Melitta, Ronco Pierre

Abstract excerpt

L1, a member of the immunoglobulin superfamily, is a cell adhesion and signal transducing molecule. In the kidney, L1 is expressed in the mesonephric duct and the metanephros throughout collecting duct development. We show that mice with a targeted deletion of the L1 gene display diverse renal malformations including (i) a duplex kidney with two ureters partially or totally separated, accompanied by...

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Source

Identifiers

PMID: 12386285
DOI: 10.1093/ndt/17.suppl_9.42

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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