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Article

Disruption of Hox9,10,11 function results in cellular level lineage infidelity in the kidney.

Scientific reports - 20 Apr 2018

Drake Keri A, Adam Mike, Mahoney Robert, Potter S Steven

Abstract excerpt

Hox genes are important regulators of development. The 39 mammalian Hox genes have considerable functional overlap, greatly confounding their study. In this report, we generated mice with multiple combinations of paralogous and flanking Abd-B Hox gene mutations to investigate functional redundancies in kidney development. The resulting mice developed a number of kidney abnormalities, including hypoplasia,...

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Share to Cell Differentiation
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 29679048
DOI: 10.1038/s41598-018-24782-5
PMCID: PMC5910417

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