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Article

Nonsense-mediated mRNA decay mutes the splicing defects of spliceosome component mutations.

RNA (New York, N.Y.) - 1 Dec 2009

Kawashima Tadashi, Pellegrini Matteo, Chanfreau Guillaume F

Abstract excerpt

The role of many splicing factors in pre-mRNA splicing and the involvement of these factors in the processing of specific transcripts have often been defined through the analysis of loss-of-function mutants in vivo. Here we show that inactivating the nonsense-mediated mRNA decay (NMD) results in an enhancement of splicing phenotypes associated with several S. cerevisiae splicing factor mutations. Tiling...

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Source

Open in PubMed Open full text

Identifiers

PMID: 19850912
DOI: 10.1261/rna.1736809
PMCID: PMC2779665

Genes

UPF1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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