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Article

A targeted bypass screen identifies Ynl187p, Prp42p, Snu71p, and Cbp80p for stable U1 snRNP/Pre-mRNA interaction.

Molecular and cellular biology - 1 Jul 2009

Hage Rosemary, Tung Luh, Du Hansen, Stands Leah, Rosbash Michael, Chang Tien-Hsien

Abstract excerpt

To understand how DEXD/H-box proteins recognize and interact with their cellular substrates, we have been studying Prp28p, a DEXD/H-box splicing factor required for switching the U1 snRNP with the U6 snRNP at the precursor mRNA (pre-mRNA) 5' splice site. We previously demonstrated that the requirement for Prp28p can be eliminated by mutations that alter either the U1 snRNA or the U1C protein, suggesting that both...

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Identifiers

PMID: 19451230
DOI: 10.1128/MCB.00384-09
PMCID: PMC2704744

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Source receipt: pubmed, retrieved 7 Sept 2026.

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