Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Genomewide analysis of mRNA processing in yeast using splicing-specific microarrays.

Science (New York, N.Y.) - 3 May 2002

Clark Tyson A, Sugnet Charles W, Ares Manuel

Abstract excerpt

Introns interrupt almost every eukaryotic protein-coding gene, yet how the splicing apparatus interprets the genome during messenger RNA (mRNA) synthesis is poorly understood. We designed microarrays to distinguish spliced from unspliced RNA for each intron-containing yeast gene and measured genomewide effects on splicing caused by loss of 18 different mRNA processing factors. After accommodating changes in...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Genome, Fungal
Share to Ribonucleoprotein, U5 Small Nuclear
Share to RNA-Binding Proteins

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to RNA, Fungal

Share to RNA Precursors

Share to RNA Processing, Post-Transcriptional

Share to RNA Splicing

Share to RNA Splicing Factors

Source

Identifiers

PMID: 11988574
DOI: 10.1126/science.1069415

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Genomewide analysis of mRNA processing in yeast using splicing-specific microarrays.PMID 11988574Read ↗

Genome-wide analysis of pre-mRNA splicing: intron features govern the requirement for the second-step factor, Prp17 in Saccharomyces cerevisiae and Schizosaccharomyces pombe.Semantic proximity Read ↗

Transcript specificity in yeast pre-mRNA splicing revealed by mutations in core spliceosomal components.Semantic proximity Read ↗

Introns regulate RNA and protein abundance in yeast.Semantic proximity Read ↗

Nonsense-mediated mRNA decay mutes the splicing defects of spliceosome component mutations.Semantic proximity Read ↗

A quantitative, high-throughput reverse genetic screen reveals novel connections between Pre-mRNA splicing and 5' and 3' end transcript determinants.Semantic proximity Read ↗

Genome-wide identification of spliced introns using a tiling microarray.Semantic proximity Read ↗

Sequencing of lariat termini in S. cerevisiae reveals 5' splice sites, branch points, and novel splicing events.Semantic proximity Read ↗

Workflow for Genome-Wide Determination of Pre-mRNA Splicing Efficiency from Yeast RNA-seq Data.Semantic proximity Read ↗

Six novel genes necessary for pre-mRNA splicing in Saccharomyces cerevisiae.Semantic proximity Read ↗

Alternative mRNA processing sites decrease genetic variability while increasing functional diversity.Semantic proximity Read ↗

Interconnections Between RNA-Processing Pathways Revealed by a Sequencing-Based Genetic Screen for Pre-mRNA Splicing Mutants in Fission Yeast.Semantic proximity Read ↗

Deletion of many yeast introns reveals a minority of genes that require splicing for function.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.