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Article

Chemogenetic profiling identifies RAD17 as synthetically lethal with checkpoint kinase inhibition.

Oncotarget - 3 Nov 2015

Shen John Paul, Srivas Rohith, Gross Andrew, Li Jianfeng, Jaehnig Eric J, Sun Su Ming, Bojorquez-Gomez Ana, Licon Katherine, Sivaganesh Vignesh, Xu Jia L, Klepper Kristin, Yeerna Huwate, Pekin Daniel, Qiu Chu Ping, van Attikum Haico, Sobol Robert W, Ideker Trey

Abstract excerpt

Chemical inhibitors of the checkpoint kinases have shown promise in the treatment of cancer, yet their clinical utility may be limited by a lack of molecular biomarkers to identify specific patients most likely to respond to therapy. To this end, we screened 112 known tumor suppressor genes for synthetic lethal interactions with inhibitors of the CHEK1 and CHEK2 checkpoint kinases. We identified eight...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 26437225
DOI: 10.18632/oncotarget.5928
PMCID: PMC4742139

Genes

RAD17
CHEK1
WEE1
CHEK2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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