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CRISPR editing of <i>sftb-1</i> /SF3B1 in <i>C. elegans</i> allows the identification of synthetic interactions with cancer-related mutations and the chemical inhibition of splicing

2019-05-10

Abstract excerpt

<h4>ABSTRACT</h4> SF3B1 is the most frequently mutated splicing factor in cancer. Mutations in SF3B1 confer growth advantages to cancer cells but they may also confer vulnerabilities that can be therapeutically targeted. In contrast to other animal models, SF3B1 cancer mutations can be maintained in homozygosis in C. elegans , allowing synthetic lethal screens with a homogeneous population of animals. These mut...

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Literature Corpus work
2f4c4c6e-c988-5a34-8050-cfb83f5be1b7
DOI
10.1101/634634
Open publication

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CRISPR editing of <i>sftb-1</i> /SF3B1 in <i>C. elegans</i> allows the identification of synthetic interactions with cancer-related mutations and the chemical inhibition of splicingDOI 10.1101/634634
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