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Article

TIMP-2 gene polymorphism is associated with intracerebral hemorrhage.

Cerebrovascular diseases (Basel, Switzerland) - 1 Jan 2009

Reuter Bjoern, Bugert Peter, Stroick Mark, Bukow Simone, Griebe Martin, Hennerici Michael G, Fatar Marc

Abstract excerpt

BACKGROUND: Both ischemic stroke and intracerebral hemorrhage are associated with altered expression and activation of matrix metalloproteinases (MMPs). Particularly relevant are MMP-2 and MMP-9. This proteolytic effect is dampened by tissue inhibitors of metalloproteinases (TIMPs). TIMP-2 is an important endogenous inhibitor of MMP-2. Alterations in the TIMP-2 gene expression may contribute to the incidence of...

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PMID: 19844095
DOI: 10.1159/000247599

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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