Article
Association of MMP-9 Haplotypes and TIMP-1 Polymorphism with Spontaneous Deep Intracerebral Hemorrhage in the Taiwan Population.
PloS one - 1 Jan 2015
Ho Wei-Min, Chen Chiung-Mei, Lee Yun-Shien, Chang Kuo-Hsuan, Chen Huei-Wen, Chen Sien-Tsong, Chen Yi-Chun
Abstract excerpt
BACKGROUND: Spontaneous deep intracerebral hemorrhage (SDICH) is a devastating stroke subtype. The causes of SDICH are heterogeneous. Matrix metalloproteinase-9 (MMP-9, Gelantinase B) has been shown to relate to stroke and the development of aneurysm and may increase risks of intracerebral hemorrhage. MMP activities are modulated by their endogenous inhibitors, tissue inhibitors of metalloproteinases (TIMPs). We...
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