Article
Single-nucleotide polymorphisms of MMP-2 gene in stroke subtypes.
Cerebrovascular diseases (Basel, Switzerland) - 1 Jan 2008
Fatar Marc, Stroick Mark, Steffens Michael, Senn Eva, Reuter Bjoern, Bukow Simone, Griebe Martin, Alonso Angelika, Lichtner Peter, Bugert Peter, Meitinger Thomas, Wienker Thomas F, Hennerici Michael G
Abstract excerpt
BACKGROUND: Matrix metalloproteinases (MMP) are expressed after ischemic stroke. These proteases are responsible for a higher incidence of hemorrhages, are correlated to size of infarction and influence the effects of recombinant tissue plasminogen activator treatment. We therefore evaluated single nucleotide polymorphisms (SNP) of MMP-2 in different subtypes of stroke patients in an association study using a...
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