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Article

TIMP-1 polymorphisms in a Chinese Han population with intracerebral hemorrhage.

The International journal of neuroscience - 1 Jan 2014

Wang Hong-Xing, Yang Qi-Dong, Liu Bao-Qiong, Zhang Le, Ma Ming-Ming, Hu Zhong-Yang, Xia Jian, Xu Hong-Wei, Du Xiao-Ping

Abstract excerpt

Remodeling of extracellular matrix (ECM) and breakdown of blood-brain barrier (BBB) are crucial events in the pathogenesis of intracerebral hemorrhage (ICH). Matrix metalloproteinases (MMPs), particularly MMP-9 and MMP-2, are the most important degrading enzymes in the ECM and BBB. These proteolytic effects are controlled predominantly by tissue inhibitors of metalloproteinases (TIMPs). TIMP-1 is the main...

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Identifiers

PMID: 23841813
DOI: 10.3109/00207454.2013.823604

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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