Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Regulatory allospecific NK cell function is differentially associated with HLA C allotypes.

American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons - 1 Nov 2009

Zenhaeusern G, Gasser O, Hönger G, Durovic B, Stern M, Hess C

Abstract excerpt

Major histocompatibility complex I (MHC I) molecules 'silence' natural killer (NK) cell activity. Conversely, NK cell activity is triggered through cells lacking expression of autologous MHC I. Unexpectedly we found that a subset of NK cells is activated rather than silenced when interacting with cells expressing normal levels of autologous MHC I. Instead of inducing an inflammatory phenotype, however, activation...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to HLA-C Antigens
Share to Interferon-gamma

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Interleukin-10

Share to Isoantigens

Share to Killer Cells, Natural

Share to Lymphocyte Culture Test, Mixed

Share to Transforming Growth Factor beta

Share to Transplantation Immunology

Source

Identifiers

PMID: 19843037
DOI: 10.1111/j.1600-6143.2009.02808.x

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Regulatory allospecific NK cell function is differentially associated with HLA C allotypes.PMID 19843037Read ↗

KIR2DS1-mediated activation overrides NKG2A-mediated inhibition in HLA-C C2-negative individuals.Semantic proximity Read ↗

Independent contributions of HLA epitopes and killer inhibitory receptor expression to the functional alloreactive specificity of natural killer cells.Semantic proximity Read ↗

HLA-E Peptide Repertoire and Dimorphism—Centerpieces in the Adaptive NK Cell Puzzle?Semantic proximity Read ↗

NKG2D and natural cytotoxicity receptors are involved in natural killer cell interaction with self-antigen presenting cells and stromal cells.Semantic proximity Read ↗

HLA-C is the inhibitory ligand that determines dominant resistance to lysis by NK1- and NK2-specific natural killer cells.Semantic proximity Read ↗

Canonical and cross-reactive binding of NK cell inhibitory receptors to HLA-C allotypes is dictated by peptides bound to HLA-CSemantic proximity Read ↗

Autologous and allogeneic HLA KIR ligand environments and activating KIR control KIR NK-cell functions.Semantic proximity Read ↗

Generation of allospecific natural killer cells by stimulation across a polymorphism of HLA-C.Semantic proximity Read ↗

Protection from lysis by natural killer cells of group 1 and 2 specificity is mediated by residue 80 in human histocompatibility leukocyte antigen C alleles and also occurs with empty major histocompatibility complex molecules.Semantic proximity Read ↗

Regulation of the NK cell alloreactivity to bone marrow cells by the combination of the host NK gene complex and MHC haplotypes.Semantic proximity Read ↗

General role of HLA class I molecules in the protection of target cells from lysis by natural killer cells: evidence that the free heavy chains of class I molecules are not sufficient to mediate the protective effect.Semantic proximity Read ↗

Direct binding and functional transfer of NK cell inhibitory receptors reveal novel patterns of HLA-C allotype recognition.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.