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Article

Generation of allospecific natural killer cells by stimulation across a polymorphism of HLA-C.

Science (New York, N.Y.) - 21 May 1993

Colonna M, Brooks E G, Falco M, Ferrara G B, Strominger J L

Abstract excerpt

The cytotoxicity of human natural killer (NK) cells is modulated by the major histocompatibility complex human leukocyte antigen (HLA)-C molecules on the surface of the target cell. Alloreactive NK cells specific for the NK-1 alloantigen could be reproducibly generated from individuals that were...

Topics

Alleles
Animals
Base Sequence
Cell Line
Cytotoxicity, Immunologic
Genotype
HLA-C Antigens
Heterozygote
Homozygote
Humans
Isoantigens
Killer Cells, Natural
Mice

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Molecular Sequence Data

Oligodeoxyribonucleotides

Polymorphism, Genetic

Source

Identifiers

PMID: 8493555
DOI: 10.1126/science.8493555

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026. Prepared record publication-8493555-2026-08-30.1. Manifest publication-graph-cohort-2026-08-30.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 30 Aug 2026.

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