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Article

Generation of allospecific natural killer cells by stimulation across a polymorphism of HLA-C.

Science (New York, N.Y.) - 21 May 1993

Colonna M, Brooks E G, Falco M, Ferrara G B, Strominger J L

Abstract excerpt

The cytotoxicity of human natural killer (NK) cells is modulated by the major histocompatibility complex human leukocyte antigen (HLA)-C molecules on the surface of the target cell. Alloreactive NK cells specific for the NK-1 alloantigen could be reproducibly generated from individuals that were homozygous for HLA-C with asparagine at residue 77 and lysine at residue 80 [HLA-C(Asn77,Lys80)] by stimulation with...

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PMID: 8493555
DOI: 10.1126/science.8493555

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

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