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Article

Regulation of the NK cell alloreactivity to bone marrow cells by the combination of the host NK gene complex and MHC haplotypes.

Journal of immunology (Baltimore, Md. : 1950) - 1 Mar 2008

Iizuka Koho, Scalzo Anthony A, Xian Hong, Yokoyama Wayne M

Abstract excerpt

Host NK cells can reject MHC-incompatible (allogeneic) bone marrow cells (BMCs), suggesting their effective role for graft-vs leukemia effects in the clinical setting of bone marrow transplantation. NK cell-mediated rejection of allogeneic BMCs is dependent on donor and recipient MHC alleles and other factors that are not yet fully characterized. Whereas the molecular mechanisms of allogeneic MHC recognition by...

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PMID: 18292550
DOI: 10.4049/jimmunol.180.5.3260

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

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