Article
General role of HLA class I molecules in the protection of target cells from lysis by natural killer cells: evidence that the free heavy chains of class I molecules are not sufficient to mediate the protective effect.
International immunology - 1 Mar 1995
Ciccone E, Pende D, Nanni L, Di Donato C, Viale O, Beretta A, Vitale M, Sivori S, Moretta A, Moretta L
Abstract excerpt
Some HLA-C alleles have been shown to exert a specific protective effect preventing target cells from lysis by groups of natural killer (NK) clones displaying a defined specificity. In this study, we analyzed whether class I-mediated protection is a more general phenomenon involving all NK cells. First, we utilized two anti-class I mAbs (6A4 of IgG1 isotype and A6-136 of IgM isotype), which had been shown to...
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