Article
A hypersensitive estrogen receptor alpha mutation that alters dynamic protein interactions.
Breast cancer research and treatment - 1 Jul 2010
Herynk Matthew H, Hopp Torsten, Cui Yukun, Niu Airu, Corona-Rodriguez Arnoldo, Fuqua Suzanne A W
Abstract excerpt
Estrogen receptor alpha (ERalpha) is highly regulated through multiple mechanisms including cell signaling, posttranslational modifications, and protein-protein interactions. We have previously identified a K303R ERalpha mutation within the hinge region of ERalpha. This mutation results in an altered posttranslational regulation and increased in vitro growth in the presence of low estrogen concentrations. We...
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