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Article

Neomorphic ERα Mutations Drive Progression in Breast Cancer and Present a Challenge for New Drug Discovery.

Cancer cell - 12 Feb 2018

McDonnell Donald P, Norris John D, Chang Ching-Yi

Abstract excerpt

In this issue of Cancer Cell, Jeselsohn et al. dissect the function of several of the most clinically important estrogen receptor alpha mutants associated with endocrine therapy resistance in breast cancer and demonstrate that they manifest disease-relevant neomorphic activities that likely contribute to tumor pathogenesis.

Read the complete abstract on PubMed

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Share to Breast Neoplasms
Share to Cell Line, Tumor
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Drug Resistance, Neoplasm

Share to Estrogen Receptor alpha

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Source

Identifiers

PMID: 29438688
DOI: 10.1016/j.ccell.2018.01.014

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026.

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