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Growth factor-induced resistance to tamoxifen is associated with a mutation of estrogen receptor alpha and its phosphorylation at serine 305.

Breast cancer research and treatment - 1 Jan 2010

Giordano Cinzia, Cui Yukun, Barone Ines, Ando Sebastiano, Mancini Michael A, Berno Valeria, Fuqua Suzanne A W

Abstract excerpt

Estrogens play a crucial role in breast tumor growth, which is the rationale for the use of antiestrogens, such as tamoxifen, in women with estrogen receptor (ER)-alpha-positive breast cancer. However, hormone resistance is a major clinical problem. Altered growth factor signaling to the ERalpha pathway has been shown to be associated with the development of clinical resistance. We previously have identified a...

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Identifiers

PMID: 19205871
DOI: 10.1007/s10549-009-0334-0
PMCID: PMC4482256

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Growth factor-induced resistance to tamoxifen is associated with a mutation of estrogen receptor alpha and its phosphorylation at serine 305.PMID 19205871Read ↗

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