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Article

Tyrosine Phosphorylation of the Pioneer Transcription Factor FoxA1 Promotes Activation of Estrogen Signaling.

Journal of cellular biochemistry - 1 Jun 2017

Yamaguchi Noritaka, Shibazaki Misato, Yamada Chiaki, Anzai Erina, Morii Mariko, Nakayama Yuji, Kuga Takahisa, Hashimoto Yuuki, Tomonaga Takeshi, Yamaguchi Naoto

Abstract excerpt

The pioneer transcription factor FoxA1 plays an important role in estrogen signaling by opening closed chromatin and promoting recruitment of the estrogen receptor to its target regions in DNA. In this study, we analyzed tyrosine phosphorylation of FoxA1 by the non-receptor-type tyrosine kinase c-Abl. c-Abl was shown to phosphorylate FoxA1 at multiple sites, especially in the N- and C-terminal regions. Tyr429 and...

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Identifiers

PMID: 27883218
DOI: 10.1002/jcb.25804

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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