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Article

Phosphorylation of the mutant K303R estrogen receptor alpha at serine 305 affects aromatase inhibitor sensitivity.

Oncogene - 22 Apr 2010

Barone I, Iacopetta D, Covington K R, Cui Y, Tsimelzon A, Beyer A, Andò S, Fuqua S A W

Abstract excerpt

We earlier identified a lysine to arginine transition at residue 303 (K303R) in estrogen receptor alpha (ERalpha) in invasive breast cancers, which confers resistance to the aromatase inhibitor (AI) anastrozole (Ana) when expressed in MCF-7 breast cancer cells. Here, we show that AI resistance ar...

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Identifiers

PMID: 20101208
DOI: 10.1038/onc.2009.520
PMCID: PMC2922934

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-20101208-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

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