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Article

Genetic evidence for the aggravation of Plasmodium falciparum malaria by interleukin 4.

The Journal of infectious diseases - 15 Nov 2009

Cabantous Sandrine, Poudiougou Belco, Oumar Aboubacar A, Traore Abdoualye, Barry Abdoulaye, Vitte Joana, Bongrand Pierre, Marquet Sandrine, Doumbo Ogobara, Dessein Alain J

Abstract excerpt

BACKGROUND: Severe malaria (SM) due to Plasmodium falciparum causes millions of child deaths in sub-Saharan Africa. It comprises a variety of clinical disorders, including cerebral malaria (CM) and severe anemia (SA). In previous work, we have shown that interferon gamma and interleukin 12 protect against CM. Here, we investigated whether interleukin 4 (IL-4) aggravates the risk of severe disease. METHODS: We...

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PMID: 19835477
DOI: 10.1086/644600

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