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Article

Hemoglobin Genotypes Modulate Inflammatory Response to Plasmodium Infection.

Frontiers in immunology - 1 Jan 2020

Harp Keri Oxendine, Botchway Felix, Dei-Adomakoh Yvonne, Wilson Michael D, Hood Joshua L, Adjei Andrew A, Stiles Jonathan K, Driss Adel

Abstract excerpt

In 2018, 228 million cases and 405,000 malaria-associated deaths were reported worldwide with a majority being in Africa. A wide range of factors, including parasitemia, host immunity, inflammatory responses to infection, and host hemoglobin genotype, mediate the severity of malaria. Among the hemoglobinopathies, hemoglobin S (HbS) is caused by a single amino acid substitution of Glutamic Acid replaced by Valine...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 33424841
DOI: 10.3389/fimmu.2020.593546
PMCID: PMC7786007

Genes

SCD
CCL2
CXCL10
SCT
TNF

Provenance

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