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Article

Genotype combinations of two IL4 polymorphisms influencing IL-4 plasma levels are associated with different risks of severe malaria in the Malian population.

Immunogenetics - 1 Jun 2015

Cabantous Sandrine, Ranque Stéphane, Poudiougou Belco, Traore Abdoulaye, Berbache Sofiane, Vitte Joana, Bongrand Pierre, Doumbo Ogobara, Dessein Alain J, Abel Laurent, Marquet Sandrine

Abstract excerpt

We have previously found that children heterozygous for IL4 variable-number tandem repeat (VNTR) (rs8179190) or IL4-33 (rs2070874) variants were at risk for severe malaria (SM), whereas homozygous children were protected suggesting a complex genetic control. Hence, to dissect this complex genetic control of IL4 VNTR and IL4-33, we performed further investigation by conditional logistic regression analysis and...

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PMID: 25935236
DOI: 10.1007/s00251-015-0836-3

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