Article
Gene expression programs in response to hypoxia: cell type specificity and prognostic significance in human cancers.
PLoS medicine - 1 Mar 2006
Chi Jen-Tsan, Wang Zhen, Nuyten Dimitry S A, Rodriguez Edwin H, Schaner Marci E, Salim Ali, Wang Yun, Kristensen Gunnar B, Helland Aslaug, Børresen-Dale Anne-Lise, Giaccia Amato, Longaker Michael T, Hastie Trevor, Yang George P, van de Vijver Marc J, Brown Patrick O
Abstract excerpt
BACKGROUND: Inadequate oxygen (hypoxia) triggers a multifaceted cellular response that has important roles in normal physiology and in many human diseases. A transcription factor, hypoxia-inducible factor (HIF), plays a central role in the hypoxia response; its activity is regulated by the oxygen-dependent degradation of the HIF-1alpha protein. Despite the ubiquity and importance of hypoxia responses, little is...
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