Article

The cistrome response to hypoxia in human umbilical vein endothelial cells

2025-03-25

Abstract excerpt

<h4>ABSTRACT</h4> Hypoxic stress triggers transcriptional signaling mainly through hypoxia-inducible transcription factors (HIFs), which bind hypoxia response elements (HREs) in gene regulatory regions. However, only a small proportion (∼1%) of known HREs are occupied by HIFs during hypoxia, suggesting the involvement of additional hypoxia-responsive factors. To address this gap, we utilized MNase-defined cistrom...

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Literature Corpus work: c070839f-c75f-5351-b248-0dde26621c14
DOI: 10.1101/2025.03.23.644824

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