Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Differential regulation of the transcriptional activities of hypoxia-inducible factor 1 alpha (HIF-1alpha) and HIF-2alpha in stem cells.

Molecular and cellular biology - 1 May 2006

Hu Cheng-Jun, Iyer Sangeeta, Sataur Aneesa, Covello Kelly L, Chodosh Lewis A, Simon M Celeste

Abstract excerpt

Transcriptional responses to hypoxia are primarily mediated by hypoxia-inducible factors (HIFs), HIF-1alpha and HIF-2alpha. The HIF-1alpha and HIF-2alpha subunits are structurally similar in their DNA binding and dimerization domains but differ in their transactivation domains, implying they may have unique target genes and require distinct transcriptional cofactors. Our previous results demonstrated that...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Aryl Hydrocarbon Receptor Nuclear Translocator
Share to Basic Helix-Loop-Helix Transcription Factors

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Hypoxia

Share to Hypoxia-Inducible Factor 1, alpha Subunit

Share to Oligonucleotide Array Sequence Analysis

Share to Stem Cells

Share to Transcriptional Activation

Share to Up-Regulation

Source

Open in PubMed Open full text

Identifiers

PMID: 16611993
DOI: 10.1128/MCB.26.9.3514-3526.2006
PMCID: PMC1447431

Genes

VHL

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Differential regulation of the transcriptional activities of hypoxia-inducible factor 1 alpha (HIF-1alpha) and HIF-2alpha in stem cells.PMID 16611993Read ↗

Biology of hypoxia-inducible factor-2alpha in development and disease.Semantic proximity Read ↗

The N-terminal transactivation domain confers target gene specificity of hypoxia-inducible factors HIF-1alpha and HIF-2alpha.Semantic proximity Read ↗

HIF-2alpha regulates Oct-4: effects of hypoxia on stem cell function, embryonic development, and tumor growth.Semantic proximity Read ↗

Expression of hypoxia-inducible factor 1: mechanisms and consequencesSemantic proximity Read ↗

Hypoxia-inducible factors: central regulators of the tumor phenotype.Semantic proximity Read ↗

Acute postnatal ablation of Hif-2alpha results in anemia.Semantic proximity Read ↗

Cancer stem cells and hypoxia-inducible factors (Review)Semantic proximity Read ↗

The transcriptional factors HIF-1 and HIF-2 and their novel inhibitors in cancer therapySemantic proximity Read ↗

Regulation of HIF prolyl hydroxylases by hypoxia-inducible factors.Semantic proximity Read ↗

The Human Hypoxia-Inducible Factor 1α Gene:HIF1AStructure and Evolutionary ConservationSemantic proximity Read ↗

Identification of Alternative Spliced Variants of Human Hypoxia-inducible Factor-1αSemantic proximity Read ↗

Preferential binding of HIF-1 to transcriptionally active loci determines cell-type specific response to hypoxiaSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.