Hypoxia Inducible Factor (HIF) transcription factor family expansion, diversification, divergence and selection in eukaryotes.

Abstract excerpt

Hypoxia inducible factor (HIF) transcription factors are crucial for regulating a variety of cellular activities in response to oxygen stress (hypoxia). In this study, we determine the evolutionary history of HIF genes and their associated transactivation domains, as well as perform selection and functional divergence analyses across their four characteristic domains. Here we show that the HIF genes are...

Topics

Share this publication in a Topic to start or enrich a Post.

• Share to Basic Helix-Loop-Helix Transcription Factors
• Share to Eukaryota
• Share to Evolution, Molecular