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Article

Setd2 regulates quiescence and differentiation of adult hematopoietic stem cells by restricting RNA polymerase II elongation.

Haematologica - 1 Jul 2018

Zhou Yile, Yan Xiaomei, Feng Xiaomin, Bu Jiachen, Dong Yunzhu, Lin Peipei, Hayashi Yoshihiro, Huang Rui, Olsson Andre, Andreassen Paul R, Grimes H Leighton, Wang Qian-Fei, Cheng Tao, Xiao Zhijian, Jin Jie, Huang Gang

Abstract excerpt

SET domain containing 2 (Setd2), encoding a histone methyltransferase, is associated with many hematopoietic diseases when mutated. By generating a novel exon 6 conditional knockout mouse model, we describe an essential role of Setd2 in maintaining the adult hematopoietic stem cells. Loss of Setd2 results in leukopenia, anemia, and increased platelets accompanied by hypocellularity, erythroid dysplasia, and mild...

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Share to Cell Self Renewal
Share to Gene Knockdown Techniques

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Hematopoiesis

Share to Hematopoietic Stem Cells

Share to Histone-Lysine N-Methyltransferase

Share to Peptide Chain Elongation, Translational

Share to Resting Phase, Cell Cycle

Share to RNA Polymerase II

Source

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Identifiers

PMID: 29650642
DOI: 10.3324/haematol.2018.187708
PMCID: PMC6029524

Genes

SET

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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