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Article

Molecular drivers of lobular carcinoma in situ.

Breast cancer research : BCR - 4 Jun 2015

Logan Greg J, Dabbs David J, Lucas Peter C, Jankowitz Rachel C, Brown Daniel D, Clark Beth Z, Oesterreich Steffi, McAuliffe Priscilla F

Abstract excerpt

Lobular carcinoma in situ (LCIS) is considered to be a risk factor for the development of invasive breast carcinoma, but it may also be a non-obligate precursor to invasive lobular carcinoma (ILC). Many LCIS lesions do not progress to ILC, and the molecular changes that are necessary for progression from LCIS to ILC are poorly understood. Disruption in the E-cadherin complex is the hallmark of lobular lesions,...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 26041550
DOI: 10.1186/s13058-015-0580-5
PMCID: PMC4453073

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