Breast ductal carcinoma in situ carry mutational driver events representative of invasive breast cancer.

doi:10.1038/modpathol.2017.21

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Article

Breast ductal carcinoma in situ carry mutational driver events representative of invasive breast cancer.

Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc - 1 Jul 2017

Pang Jia-Min B, Savas Peter, Fellowes Andrew P, Mir Arnau Gisela, Kader Tanjina, Vedururu Ravikiran, Hewitt Chelsee, Takano Elena A, Byrne David J, Choong David Yh, Millar Ewan Ka, Lee C Soon, O'Toole Sandra A, Lakhani Sunil R, Cummings Margaret C, Mann G Bruce, Campbell Ian G, Dobrovic Alexander, Loi Sherene, Gorringe Kylie L, Fox Stephen B

Abstract excerpt

The spectrum of genomic alterations in ductal carcinoma in situ (DCIS) is relatively unexplored, but is likely to provide useful insights into its biology, its progression to invasive carcinoma and the risk of recurrence. DCIS (n=20) with a range of phenotypes was assessed by massively parallel sequencing for mutations and copy number alterations and variants validated by Sanger sequencing. PIK3CA mutations were...

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Identifiers

PMID: 28338653
DOI: 10.1038/modpathol.2017.21

Genes

GATA3
ERBB2
RUNX1

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