Article
PIK3CA mutations in in situ and invasive breast carcinomas.
Cancer research - 15 Jul 2010
Miron Alexander, Varadi Maria, Carrasco Daniel, Li Hailun, Luongo Lauren, Kim Hee Jung, Park So Yeon, Cho Eun Yoon, Lewis Gretchen, Kehoe Sarah, Iglehart J Dirk, Dillon Deborah, Allred D Craig, Macconaill Laura, Gelman Rebecca, Polyak Kornelia
Abstract excerpt
The PIK3 signaling pathway has been identified as one of the most important and most frequently mutated pathways in breast cancer. Somatic mutations in the catalytic subunit of PIK3CA have been found in a significant fraction of breast carcinomas, and it has been proposed that mutant PIK3CA plays a role in tumor initiation. However, the majority of primary human tumors analyzed for genetic alterations in PIK3CA...
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