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Article

PI3K pathway activation in high-grade ductal carcinoma in situ--implications for progression to invasive breast carcinoma.

Clinical cancer research : an official journal of the American Association for Cancer Research - 1 May 2014

Sakr Rita A, Weigelt Britta, Chandarlapaty Sarat, Andrade Victor P, Guerini-Rocco Elena, Giri Dilip, Ng Charlotte K Y, Cowell Catherine F, Rosen Neal, Reis-Filho Jorge S, King Tari A

Abstract excerpt

PURPOSE: To assess the prevalence of phosphoinositide 3-kinase (PI3K) pathway alterations in pure high-grade ductal carcinoma in situ (DCIS) and DCIS associated with invasive breast cancer (IBC), and to determine whether DCIS and adjacent IBCs harbor distinct PI3K pathway aberrations. EXPERIMENTAL DESIGN: Eighty-nine cases of pure high-grade DCIS and 119 cases of high-grade DCIS associated with IBC were...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 24634376
DOI: 10.1158/1078-0432.CCR-13-2267
PMCID: PMC4015460

Genes

AKT1
PTEN

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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