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Article

Secreted protein acidic and rich in cysteine (SPARC) gene polymorphism association with hepatocellular carcinoma in Italian patients.

Journal of gastroenterology and hepatology - 1 Dec 2009

Segat Ludovica, Milanese Michele, Pirulli Doroti, Trevisiol Chiara, Lupo Francesco, Salizzoni Mauro, Amoroso Antonio, Crovella Sergio

Abstract excerpt

BACKGROUND AND AIM: Hepatocellular carcinoma (HCC) is a multifactorial disease driven by both genetic and epigenetic factors. Infection, inflammation and the immune response against hepatitis B virus and hepatitis C virus have been shown to play an important role in increasing cancer risk and promoting tumor development. In order to investigate the genetic component influencing HCC development, we analyzed 50...

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Source

Identifiers

PMID: 19817957
DOI: 10.1111/j.1440-1746.2009.06009.x

Genes

SPARC

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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