Article
Polymorphism of A133S and promoter hypermethylation in Ras association domain family 1A gene (RASSF1A) is associated with risk of esophageal and gastric cardia cancers in Chinese population from high incidence area in northern China.
BMC cancer - 25 May 2013
Zhou Sheng Li, Cui Juan, Fan Zong Min, Li Xue Min, Li Ji Lin, Liu Bao Chi, Zhang Dong Yun, Liu Hong Yan, Zhao Xue Ke, Song Xin, Wang Ran, Yan Ze Chen, Yi Hui Xing, Wang Li Dong
Abstract excerpt
BACKGROUND: The role of tumor suppressor gene RASSF1A in the esophageal and gastric cardia carcinogenesis is still inconclusive. In this study, the polymorphism, promoter methylation and gene expression of RASSF1A were characterized in esophageal squamous cell carcinoma (ESCC) and gastric cardia adenocarcinoma (GCA). METHODS: We firstly analyzed the prevalence of RASSF1A A133S in a total of 228 cancer patients...
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