SPP1 polymorphisms associated with HBV clearance and HCC occurrence.

doi:10.1093/ije/dym093

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Article

SPP1 polymorphisms associated with HBV clearance and HCC occurrence.

International journal of epidemiology - 1 Oct 2007

Shin Hyoung Doo, Park Byung Lae, Cheong Hyun Sub, Yoon Jung-Hwan, Kim Yoon Jun, Lee Hyo-Suk

Abstract excerpt

BACKGROUND: Secreted phosphoprotein-1 (SPP1) is a secreted arginine-glycine-aspartate (RGD)-containing phosphoprotein. SPP1 is overexpressed in metastatic hepatocellular carcinoma (HCC), and therefore could act as both a diagnostic marker and a potential therapeutic target for metastatic HCC. We investigated the genetic polymorphisms in SPP1 to determine whether it is a potential candidate gene for a host genetic...

Topics

Adult
Age of Onset
Aged
Aged, 80 and over
Carcinoma, Hepatocellular
Chromosome Mapping
Disease Progression
Female
Gene Frequency
Genetic Predisposition to Disease
Genotype

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Haplotypes

Hepatitis B virus

Hepatitis B, Chronic

Humans

Liver Neoplasms

Logistic Models

Male

Source

Open in PubMed

Identifiers

PMID: 17496055
DOI: 10.1093/ije/dym093

Genes

SPP1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 31 Aug 2026.

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