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Article

Association of novel polymorphisms with the expression of SPARC in normal fibroblasts and with susceptibility to scleroderma.

Arthritis and rheumatism - 1 Nov 2002

Zhou Xiaodong, Tan Filemon K, Reveille John D, Wallis Debra, Milewicz Dianna M, Ahn Chul, Wang Andrew, Arnett Frank C

Abstract excerpt

OBJECTIVE: Fibroblasts from patients with systemic sclerosis (SSc) have an activated phenotype characterized by increased synthesis of extracellular matrix (ECM) components. SPARC (secreted protein, acidic and rich in cysteine) regulates the deposition or assembly of ECM components. The aim of th...

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Source

Identifiers

PMID: 12428242
DOI: 10.1002/art.10601

Genes

SPARC

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026. Prepared record publication-12428242-2026-09-04.2. Manifest publication-graph-cohort-2026-09-04.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 4 Sept 2026.

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